Kinetic studies on the irinotecan release based on structural properties of functionalized mesoporous-silica supports

Building a detailed kinetic model for the drug release from an ordered mesoporous support is a difficult task due to various physico-chemical processes involved, including complex adsorption–desorption and diffusion steps. A compartmented mechanistic model for the drug release from a silica mesoporous (functionalized) support is elaborated to correlate the experimental drug release data under various release conditions. The identified model parameters are interpreted in relationship to the delivery system characteristics (drug, support, and linker properties) to be used for designing a system with a controlled release. Extended model predictions are compared with those of various semi-empirical or overall diffusion models in terms of quality (adequacy, validity, reliability) and parameter significance to determine the information loss when simplified models are used for design purposes. Exemplification is made for the release of irinotecan from a MCM-41 support unfunctionalized vs. functionalized with 3-aminopropyl triethoxysilane or triethoxyvinylsilane in a synthetic intestinal fluid.

MCM-41 carrier was functionalized with 3-aminopropyl triethoxysilane or triethoxyvinylsilane to study the irinotecan release under various conditions. The drug-carrier system characteristics have been correlated to the drug release rate by means of a proposed extended kinetic model. The model advantages have been pointed out by interpreting the model parameter significance.Figure optionsDownload as PowerPoint slideHighlights
► MCM-41 was functionalized with 3-aminopropyl triethoxysilane or triethoxyvinylsilane.
► Irinotecan release from modified MCM-41 support was studied under various conditions.
► An extended model correlates the system characteristics to the drug release rate.
► Model parameters are interpreted and predictions compared to those of lumped models.