کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
74146 49081 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro elimination of protein bound uremic toxin p-cresol by MFI-type zeolites
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
In vitro elimination of protein bound uremic toxin p-cresol by MFI-type zeolites
چکیده انگلیسی

The removal of uremic toxins by zeolites is investigated in the context of the exploration of alternative methods to blood purification by dialysis. The case of a partially protein bound molecule, p-cresol, is studied here. High silica MFI type zeolites show a selective adsorption for p-cresol without major ion exchange with the cations present under equilibrium conditions in solution. Adsorption isotherms in different media were performed: pure water, artificial blood serum containing bovine serum albumin and human serum (HS obtained from a pool of 50 dialysis patients). p-Cresol elimination levels of 80–85% were obtained under in vitro conditions. However, in HS, p-cresol affinities for the zeolites are generally reduced as compared with pure water due to a partial obstruction of the pore system by adsorption of proteins on the external surface of zeolites particles. These results show that zeolites can be successfully employed as specific adsorbents for uremic toxins but without direct contact with serum albumin, which means only in the ultra-filtrate.

Figure optionsDownload as PowerPoint slideHighlights
► High silica MFI zeolites show selective adsorption for p-cresol in solution.
► Adsorption isotherms in aqueous media performed containing BSA, and in vitro (HS).
► Zeolites to be applied without direct contact with serum albumin (ultra-filtrate).
► Completion of haemodialysis procedures by zeolite based selective adsorption units.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 153, 1 May 2012, Pages 288–293
نویسندگان
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