A facile method for hemoglobin encapsulation in silica nanoparticles and application in biosensors

A facile approach for hemoglobin (Hb) encapsulation in silica nanoparticles (HbSNs) is reported. The results display that the HbSN keeps its structures. The stability of the encapsulated HbSN is significantly increased compared to that of free one at 4 °C in a buffer of pH 7.4. Moreover, the experiments of HbSN catalytic reduction of H2O2 and electrocatalytic reduction of O2 indicate that the strategy could enhance the activity of Hb, and exhibit promising applications in biosensors, biofuel cell and so on.

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► A facile and mild route for Hb encapsulated in silica nanoparticles is reported.
► The nanoparticles are novel donut-like structures.
► The storage stability and thermal stability are obviously enhanced.
► The bioelectrocatalytic activities are retaining.