کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
74285 49087 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Large-pore mesoporous silica-coated magnetite core-shell nanocomposites and their relevance for biomedical applications
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
پیش نمایش صفحه اول مقاله
Large-pore mesoporous silica-coated magnetite core-shell nanocomposites and their relevance for biomedical applications
چکیده انگلیسی

A facile synthesis for the coating of magnetic nanoparticles with large-pore, uniform mesoporous silica shells is reported. The applied procedure provides easily separable core-shell particles with discrete morphology after all production steps, crucial for any biomedical application. The large-pore sizes obtained (7 nm) paves the way for the porous shell to host also larger biomolecules than possible for standard mesoporous silica-coated particles with 3 nm pores, suitable mostly for hosting small-molecular drugs. Moreover, the synthesis is performed under neutral conditions, which prevent the magnetite (iron oxide) core from leaching/dissolving into the synthesis liquid. The same synthesis regime adapted to the corresponding standard acidic large-pore mesoporous silica synthesis conditions moreover proved to be unsuccessful, which may be a reason why syntheses of large-pore silica shells leading to discrete particles instead of particle agglomerates has to our knowledge not previously been reported in the literature.

Figure optionsDownload as PowerPoint slideHighlights
► Coating of magnetic nanoparticles with large-pore, uniform mesoporous silica shells.
► Synthesis performed under neutral conditions preserves the magnetite core.
► Shells not attainable using standard Pluronic-templated synthesis conditions.
► The large-pore sizes paves the way for the porous shell to host biomolecules.
► A highly versatile platform for functional nanomaterial engineering.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microporous and Mesoporous Materials - Volume 145, Issues 1–3, November 2011, Pages 14–20
نویسندگان
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