Surface functionalization of SBA-15 particles for amoxicillin delivery

The hydrothermally synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method with (3-aminopropyl) triethoxy silane, mercaptopropyl trimethoxy silane and triethoxy methyl silane in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. The adsorption and release properties of calcined and organic-functionalized mesoporous silicas containing terminal primary amine, organothiol and methyl groups toward amoxicillin have been investigated. These mesoporous materials have been characterized using small-angle X-ray scattering (SAXS), fourier-transform infra-red spectroscopy (FT-IR), transmission electron microscopy (TEM), N2 adsorption/desorption analysis, solid-state silicon magic-angle-spinning nuclear magnetic resonance (Si–MAS–NMR), high-performance liquid chromatography (HPLC), ultra-violet spectroscopy (UV), elemental and thermogravimetric analysis (TGA). The concentration difference and type of alkoxysilanes used for the surface functionalization have been discussed in terms of loading amoxicillin and controlling its delivery.

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► Investigation of adsorption/release properties of samples after functionalization.
► Chemical modification with primary amine, organothiol and methyl groups.
► Enhancement of the amount of amoxicillin incorporation and controlling its delivery.
► Amino propyl modified samples possess the highest efficiency of functionalization.
► Potential application of SBA-15 particles as drug delivery systems.