Stability studies of extracellular domain two of neural-cadherin

►E- and N-cadherin have different stability and calcium-dependent dimerization. ►Ectodomains were characterized individually to find the origin of these differences. ►Domain 2 for E- and N-cadherins differ in number and distribution of charges. ►Salt-dependent differences in stability correlate with differences in charge. ►Difference between E- and N-cadherin affects stability and perhaps dimerization.