کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7561571 1491476 2018 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological activity of 5‑bromo‑2-chloropyrimidin-4-amine derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Synthesis and biological activity of 5‑bromo‑2-chloropyrimidin-4-amine derivatives
چکیده انگلیسی
A series of novel 5‑bromo‑2-chloropyrimidin-4-amine derivatives (7a‐h and 8a‐e) were synthesized by nucleophilic substitution reaction with various sulfonyl and acid chlorides. The newly synthesized compounds were characterized by elemental analyses, FT‐IR, 1H NMR and LC‐MS spectral studies. All compounds were evaluated for its in vitro antibacterial and antifungal activities. The Compound N-(5‑bromo‑2‑chloro‑pyrimidin-4-yl)-4-methyl-benzenesulfonamide (7b) exhibited significant antimicrobial activity against tested pathogenic bacterial and fungal strains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemical Data Collections - Volumes 13–14, March 2018, Pages 1-10
نویسندگان
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