Multivariate curve resolution of nonlinear ion mobility spectra followed by multivariate nonlinear calibration for quantitative prediction

► Nonlinear IMS datasets are analyzed qualitatively and quantitatively. ► MCR-ALS is used for an optimal physical and chemical interpretation of the system. ► Multivariate nonlinear calibration methods are used for quantification. ► The proposed method provides better results especially in nonlinear datasets.