Synthesis of Boronic Acid-functionalized Soluble Dendrimers and its Application in Detection of Human Liver Microsomal Glycoprotein Based on Enzyme-linked Immunosorbent Assay

In this study, a novel water-soluble dendrimer based boric acid capture (DBC) method was developed, using PAMAM 4.0 as the carrier and boric acid as the affinity group. DBC as a novel enrichment material for glycoprotein, combined with ELISA analysis, high sensitivity and selectivity detection could be achieved in biological samples.