Accurate Determination of Isotopic Abundance of Intracellular Metabolites of Saccharopolysporaerythraea Based on Ultra Performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry

In this study, a method was established for measuring 13C isotopic abundance of intracellular metabolites of Saccharopolyspora erythraea by ultra-high performance liquid chromatography (UPLC)-triple quadrupole mass spectrometry. This method developed in this paper had a good measurement precision, and was of great significance to the isotopic abundance detection of other similar metabolites.