کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7584374 | 1492024 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of low molecular weight phenolic compounds in gerbil plasma after the consumption of calafate berry (Berberis microphylla) extract
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Phenylacetic acid (PubChem CID: 999)3,4-Dihydroxyphenylacetic acid (PubChem CID: 547)GC–MS - GC-MSp-Coumaric acid (PubChem CID: 637542) - p-Coumaric اسید (PubChem CID: 637542)Syringic acid (PubChem CID: 10742) - اسید سیرینژیک (PubChem CID: 10742)Phenolic acid - اسید فنولیکVanillic acid (PubChem CID: 8468) - اسید وانیلیک (PubChem CID: 8468)Pharmacokinetics - فارماکوکینتیکBioavailability - فراهم زیستیPlasma - پلاسما
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Calafate is a berry with high concentration of anthocyanins and hydroxycinnamic acids that grows in South Patagonia. To date, no metabolism studies of phenolic compounds using calafate have been carried out. A calafate extract was characterized by HPLC-DAD-ESI-MS/MS. After extract administration (300â¯mg/kg), a pharmacokinetic study of phenolic compounds in gerbil plasma was performed by GC-MS/MS. Sixteen phenolic acids increased after intake. Phenylacetic acid derivatives exhibit the highest concentration, while main increase of phenolic catabolites was observed 2â¯h post-intake. 3-hydroxyphenylacetic and phenylacetic acids increased at 4-8â¯h post-intake. All catabolites found in gerbil plasma exhibit concentration peaks between 0.1 and 1â¯ÂµM, however no parental anthocyanins were detected. Establish in vivo plasmatic concentration ranges of phenolic compounds derived from polyphenol consumption following WHO recommendations, plays a key role to carry out future in vitro assays in order to correctly assign biological benefits of calafate berry consumption.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 268, 1 December 2018, Pages 347-354
Journal: Food Chemistry - Volume 268, 1 December 2018, Pages 347-354
نویسندگان
Luis Bustamante, Edgar Pastene, Daniel Duran-Sandoval, Carola Vergara, Dietrich Von Baer, Claudia Mardones,