کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7584374 | 1492024 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Pharmacokinetics of low molecular weight phenolic compounds in gerbil plasma after the consumption of calafate berry (Berberis microphylla) extract
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کلمات کلیدی
Phenylacetic acid (PubChem CID: 999)3,4-Dihydroxyphenylacetic acid (PubChem CID: 547)GC–MS - GC-MSp-Coumaric acid (PubChem CID: 637542) - p-Coumaric اسید (PubChem CID: 637542)Syringic acid (PubChem CID: 10742) - اسید سیرینژیک (PubChem CID: 10742)Phenolic acid - اسید فنولیکVanillic acid (PubChem CID: 8468) - اسید وانیلیک (PubChem CID: 8468)Pharmacokinetics - فارماکوکینتیکBioavailability - فراهم زیستیPlasma - پلاسما
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Pharmacokinetics of low molecular weight phenolic compounds in gerbil plasma after the consumption of calafate berry (Berberis microphylla) extract Pharmacokinetics of low molecular weight phenolic compounds in gerbil plasma after the consumption of calafate berry (Berberis microphylla) extract](/preview/png/7584374.png)
چکیده انگلیسی
Calafate is a berry with high concentration of anthocyanins and hydroxycinnamic acids that grows in South Patagonia. To date, no metabolism studies of phenolic compounds using calafate have been carried out. A calafate extract was characterized by HPLC-DAD-ESI-MS/MS. After extract administration (300â¯mg/kg), a pharmacokinetic study of phenolic compounds in gerbil plasma was performed by GC-MS/MS. Sixteen phenolic acids increased after intake. Phenylacetic acid derivatives exhibit the highest concentration, while main increase of phenolic catabolites was observed 2â¯h post-intake. 3-hydroxyphenylacetic and phenylacetic acids increased at 4-8â¯h post-intake. All catabolites found in gerbil plasma exhibit concentration peaks between 0.1 and 1â¯ÂµM, however no parental anthocyanins were detected. Establish in vivo plasmatic concentration ranges of phenolic compounds derived from polyphenol consumption following WHO recommendations, plays a key role to carry out future in vitro assays in order to correctly assign biological benefits of calafate berry consumption.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 268, 1 December 2018, Pages 347-354
Journal: Food Chemistry - Volume 268, 1 December 2018, Pages 347-354
نویسندگان
Luis Bustamante, Edgar Pastene, Daniel Duran-Sandoval, Carola Vergara, Dietrich Von Baer, Claudia Mardones,