کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7584576 1492026 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids
ترجمه فارسی عنوان
مشتقات اسید کلروژنریک اسید بازدارنده آلدوید ردوکتاز و آنتی اکسیدان های جدید که توسط حرارت دادن اسید کلروژنیک و اسید آمینه دریافت می شوند
کلمات کلیدی
آلدووز ردوکتاز، آنتی اکسیدان، اسید کلروژنیک، اسید گلوتامیک، سیستم مدل گرمایش
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
A heating model system (HMS) of chlorogenic acid (CGA) and 20 amino acids was produced by heating at 120 °C for 4 h and evaluated for in vitro antioxidant and aldose reductase (AR). The CGA-glutamic acid (GT) HMS showed high in vitro antiradical activity indicated by ABTS+ (82.37%) and DPPH radical scavenging (83.21%) as well as AR (83.21%) inhibition. The structure of the new compound was established by NMR spectroscopy, as methyl-3-(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)-4,5-dihydroxycyclohexanecarboxylate (1) and 4-O-caffeoylquinic acid (2) from the CGA-GT HMS. The IC50 values of compound 1 for ABTS+, DPPH and AR were 8.21, 56.97 and 3.68 μM, respectively. These activities were similar to or higher than those of known positive controls (5.49, 63.58 and 13.60 μM). We suggest that heat treatment generates novel CGA-GT HMS with increased antioxidant and AR inhibitory effects and contributes to the development of novel functional materials from CGA food products.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 266, 15 November 2018, Pages 449-457
نویسندگان
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