کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7584824 | 1492028 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative HPLC-MS/MS analysis of toxins in soapberry seeds: Methylenecyclopropylglycine and hypoglycin A
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کلمات کلیدی
lRLpercent relative standard deviationDNS-ClFDAHypoglycemic encephalopathyHypoglycin AMCPGISTDHGAPPEdeionizedAVESapindaceaeESISPECDCMRMU.S. Food and Drug Administration - اداره غذا و داروی ایالات متحدهSolid-phase extraction - استخراج فاز جامدstandard deviation - انحراف معیارPersonal protective equipment - تجهیزات حفاظتی شخصیLOD یا Limit of detection - حد تشخیصDansyl chloride - دانسیل کلرایدAverage concentration - متوسط غلظتlimit of detection - محدودیت تشخیصCenters for Disease Control and Prevention - مراکز کنترل و پیشگیری از بیماریMultiple-reaction monitoring - نظارت چند واکنشquality control - کنترل کیفیتelectrospray ionization - یونیزاسیون الکترو اسپری
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Methylenecyclcopropylglycine (MCPG) and hypoglycin A (HGA) are naturally occurring amino acids found in various soapberry (Sapindaceae) fruits. These toxins have been linked to illnesses worldwide and were recently implicated in Asian outbreaks of acute hypoglycemic encephalopathy. In a previous joint agricultural and public health investigation, we developed an analytical method capable of evaluating MCPG and HGA concentrations in soapberry fruit arils as well as a clinical method for the urinary metabolites of the toxins. Since the initial soapberry method only analyzed the aril portion of the fruit, we present here the extension of the method to include the fruit seed matrix. This work is the first method to quantitate both MCPG and HGA concentrations in the seeds of soapberry fruit, including those collected during a public health investigation. Further, this is the first quantitation of HGA in litchi seeds as well as both toxins in mamoncillo and longan seeds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 264, 30 October 2018, Pages 449-454
Journal: Food Chemistry - Volume 264, 30 October 2018, Pages 449-454
نویسندگان
Aimee A. Sanford, Samantha L. Isenberg, Melissa D. Carter, Mike A. Mojica, Thomas P. Mathews, Leslie A. Harden, Gary R. Takeoka, Jerry D. Thomas, James L. Pirkle, Rudolph C. Johnson,