کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7589676 | 1492093 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Metal chelation, radical scavenging and inhibition of Aβ42 fibrillation by food constituents in relation to Alzheimer's disease
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کلمات کلیدی
l-Ascorbic acid (PubChem CID: 54670067)(−)-Epigallocatechin gallate (PubChem CID: 65064)Propyl gallate (PubChem CID: 4947)α-Tocopherol (PubChem CID: 14985) - α-توکوفرول (PubChem CID: 14985)Antioxidants - آنتی اکسیدانCaffeic acid (PubChem CID: 689043) - اسید کافئیک (PubChem CID: 689043)Gallic acid (PubChem CID: 370) - اسید گالیک (PubChem CID: 370)Metal chelators - خالدار های فلزیResveratrol (PubChem CID: 445154) - رزوراترول (PubChem CID: 445154)Vitamins - ویتامینPolyphenols - پلیفنلهاamyloid-beta peptide - پپتید آمیلوئید بتاCaffeine (PubChem CID: 2519) - کافئین (PubChem CID: 2519)Curcumin (PubChem CID: 969516) - کورکومین (PubChem CID: 969516)
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging reactive oxygen species; and suppressing the fibrillation of amyloid-beta peptide (Aβ). In this study, nine different food constituents (l-ascorbic acid, caffeic acid, caffeine, curcumin, (â)-epigallocatechin gallate (EGCG), gallic acid, propyl gallate, resveratrol, and α-tocopherol) were investigated for their effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Aβ42 fibrillation. An assay method was developed using 5-Br-PAPS to examine the complexation of Zn(II) and Cu(II). EGCG, gallic acid, and curcumin were identified as a multifunctional compounds, however their poor brain uptake might limit their therapeutic effects. The antioxidants l-ascorbic acid and α-tocopherol, with better brain uptake, deserve further investigation for specifically addressing oxidative stress within the AD brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 199, 15 May 2016, Pages 185-194
Journal: Food Chemistry - Volume 199, 15 May 2016, Pages 185-194
نویسندگان
Stephen Chan, Srinivas Kantham, Venkatesan M. Rao, Manoj Kumar Palanivelu, Hoang L. Pham, P. Nicholas Shaw, Ross P. McGeary, Benjamin P. Ross,