کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7590268 1492101 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in apoptotic factors and caspase activation pathways during the postmortem aging of beef muscle
ترجمه فارسی عنوان
تغییرات در عوامل آپوپتوتیک و مسیرهای فعال سازی کاسپاز در طی زایمان پس از انقباض عضله گوشت گاو
کلمات کلیدی
عوامل آپوپتوزی، مسیر آپوپتوتیک، کاسپاز عضله گوشت گاو سالخورده،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The pathway of apoptosis (effector caspase activation) in beef muscle cells was investigated by examining the expression of apoptotic factors during postmortem (PM) storage of beef muscle. Results showed that caspase-3 could be activated in PM beef muscle. The expression of cytochrome c increased in the cytosolic fraction but significantly decreased in the mitochondrial fraction in the early PM period, which demonstrated that cytochrome c was released from mitochondrion to cytoplasm. The expression of the anti-apoptotic factor Bcl-2 did not show any visible change, and that of pro-apoptotic factor Bax increased during PM storage. Expression of the heat-shock protein Hsp27 significantly decreased with increased PM time. These results demonstrated that the mitochondrial pathway was one of the apoptosis pathways in PM beef muscle and that Bax and Hsp27 were two key regulation factors in apoptosis in PM beef muscle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 190, 1 January 2016, Pages 110-114
نویسندگان
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