کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7597494 1492131 2014 34 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: Potential application to quantitative analysis
ترجمه فارسی عنوان
غربالگری کیفی از 116 دارو دامپزشکی در خوراک با کروماتوگرافی مایع-طیف سنجی جرمی با رزولوشن بالا: کاربرد بالقوه برای تجزیه و تحلیل کمی
کلمات کلیدی
داروهای دامپزشکی، خوراک دام، کروماتوگرافی مایع طیف سنجی جرمی زمان پرواز، غربالگری، اعتبار کافی،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a screening method covering 116 human and veterinary drugs has been developed and validated in five types of animal feed at 0.02 and 0.2 mg kg−1. After a simple extraction and dilution, the samples were analysed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF MS). Nearly all compounds tested were detected at 0.02 mg kg−1, based on the presence of the accurate-mass (de)protonated molecule. However, the identification using a second accurate-mass ion was more problematic at this level. Finally, the procedure was applied to 22 feed samples, where trimethoprim, robenidine, or α- and β-nandrolone were detected and identified. The potential applicability of the method to quantitative analysis of the compounds detected in the samples was also evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 160, 1 October 2014, Pages 313-320
نویسندگان
, , , , , ,