کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7600031 1492145 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antimicrobial activity of antihypertensive food-derived peptides and selected alanine analogues
ترجمه فارسی عنوان
فعالیت ضد میکروبی از پپتیدهای مشتق شده از غذای ضد فشار خون و آنالوگ های آلانین انتخاب شده
کلمات کلیدی
پپتیدهای حاصل از غذا، ضد میکروبی طیف سنجی جرمی، سنتز پپتید،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
This study evaluated four food-derived peptides with known antihypertensive activities for antimicrobial activity against pathogenic microorganisms, and assessed structure-function relationships using alanine analogues. The peptides (EVSLNSGYY, barley; PGTAVFK, soybean; TTMPLW, α-casein; VHLPP, α-zein) and the six alanine substitution peptides of PGTAVFK were synthesised, characterised and evaluated for antimicrobial activity using the bacteria, Escherichia coli, Staphylococcus aureus, and Micrococcus luteus and the yeast, Candida albicans. The peptides TTMPLW and PGTAVFK inhibited growth of all four microorganisms tested, with activities of a similar order of magnitude to ampicillin and ethanol controls. EVSLNSGYY inhibited the growth of the bacteria, but VHLPP showed no antimicrobial activity. The alanine analogue, PGAAVFK showed the highest overall antimicrobial activity and PGTAVFA showed no activity; overall, the activities of the analogues were consistent with their structures. Some peptides with antihypertensive activity also show antimicrobial activity, suggesting that food-derived peptides may exert beneficial effects via a number of mechanisms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 146, 1 March 2014, Pages 443-447
نویسندگان
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