Transport across Caco-2 monolayers of peptides arising from in vitro digestion of bovine milk proteins

► Casein and whey proteins were in vitro digested and applied to Caco-2 monolayers. ► Resistant peptides able to translocate across monolayers were characterised. ► Minor amount of supposed bioactive peptides were detected. ► After digestion milk proteins almost completely lost the IgE-binging properties. ► β-Lg 127-135 is a possible “immune sensitising factors” in vivo.