A water-alcohol extract of Citrus grandis whole fruits has beneficial metabolic effects in the obese Zucker rats fed with high fat/high cholesterol diet

► A Citrus grandis (L.) Osbeck var. tomentosa hort. whole fruit extract was prepared. ► The citrus extract changed the levels of metabolic hormones in obese Zucker rats. ► Cholesterol and glucose levels were also slightly but not systematically decreased. ► The prepared C. grandis extract may affect the regulation of energy metabolism. ► The exact target mechanisms of the described citrus-effects need to be clarified.