کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7602 558 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The use of a library of industrial materials to determine the nature of substrate-dependent performance of primary adherent human cells
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
The use of a library of industrial materials to determine the nature of substrate-dependent performance of primary adherent human cells
چکیده انگلیسی

We developed a library of industrial materials, which can be applied to any adherent cell type for determining cell–material interactions. Bulk and surface chemistry as well as other material properties were characterized. The library covered broad ranges of various material properties. We applied the library to primary human endothelial and epithelial cells, which play important roles in tissue engineering and biomedical applications. The results revealed that substrate stiffness was the major determinant of cell performance. The ability to grow and differentiate on stiff or more compliant materials was cell type-dependent, but cell performance was consistently best on stiff and smooth materials. These results give new insights into the nature of substrate-dependent performance of primary human cells and are potentially useful for the development of improved biomaterials. The materials of the library can be easily accessed by the scientific community to determine cell–material interactions of any adherent cell type of interest.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 33, Issue 2, January 2012, Pages 353–364
نویسندگان
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