کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7608456 1493381 2018 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Magnetic molecularly imprinted polymers for the selective determination of cocaine by ion mobility spectrometry
ترجمه فارسی عنوان
پلیمرهای حاوی مولکولی مغناطیسی برای تعیین انتخاب کوکائین با اسپکترومتری برای تحرک یون
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Magnetic molecularly imprinted polymers (MMIPs) were prepared for cocaine recognition by bulk polymerization in the presence of magnetic nanoparticles (MNPs). Two reagents (polyethylene glycol (PEG) and 3-(trimethoxysilyl)propyl methacrylate (V)) were used for MNPs modification. MMIPs were characterized and compared in terms of loading capacity, reusability, accuracy and precision for the extraction of cocaine from saliva samples. It was observed that V-MMIPs gave higher physical stability than PEG-MMIPs. Thus, V-MMIP were used for the analysis of cocaine users saliva. The developed procedure based on ion mobility spectrometry (IMS) provided limits of detection and quantification of 4 and 14 μg L−1, respectively, and recoveries in cocaine free saliva samples spiked at 80, 270 and 560 μg L−1 ranging from 80 to 99%. Results found by the proposed method were statistically comparable to those obtained by two reference procedures; a lateral flow immunoassay and an ultra-high performance liquid chromatography coupled with tandem mass spectrometry. Therefore, MMIP-IMS can be considered as a fast, selective and sensitive alternative to reference methods with affordable cost avoiding the requirement of skilled operator.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1545, 13 April 2018, Pages 22-31
نویسندگان
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