کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7609249 1493394 2018 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of charged polymer self-assemblies by multidetector thermal field-flow fractionation in aqueous mobile phases
ترجمه فارسی عنوان
مشخصه های خودمجموعه ی پلیمرهای شارژ توسط فشرده سازی جریان حرارتی مولددکتور در فازهای متحرک آبی
کلمات کلیدی
تقسیم بندی میدان حرارتی حرارتی، میسل های شارژ، پلی (وینیل پیریدین)، پلی (متاکریلیک اسید)، بلوک کوپلیمر مایل، تقسیم بندی میدان جریان،
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Charged block copolymer self-assemblies, such as charged micelles, have attracted much attention as versatile drug delivery systems due to their readily tunable characteristics such as size and surface charge. However, current column-based analytical techniques are not suitable to fractionate and comprehensively characterize charged micelles in terms of size, molar mass, chemical composition and morphology. Multidetector thermal field-flow fractionation (ThFFF) is shown to be a unique characterization platform that can be used to characterize charged micelles in terms of size, molar mass, chemical composition and morphology in aqueous mobile phases with various ionic strengths and pH. This is demonstrated by the characterization of poly(methacrylic acid)-b-poly(methyl methacrylate) self-assemblies in high pH buffers as well as the characterization of cationic poly(2-vinyl pyridine)-b-polystyrene and poly(4-vinyl pyridine)-b-polystyrene self-assemblies in low pH buffers. Moreover, it is shown that ThFFF is capable of separating charged micelles according to the corona composition. These investigations prove convincingly that ThFFF is broadly applicable to the comprehensive characterization of amphiphilic self-assemblies even when aqueous mobile phases are used.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1532, 12 January 2018, Pages 175-181
نویسندگان
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