Determination of glutaraldehyde in water samples by headspace solid-phase microextraction and gas chromatography-mass spectrometry after derivatization with 2,2,2-trifluoroethylhydrazine

A simple and convenient headspace solid-phase microextraction (HS-SPME) gas chromatography mass spectrometry (GC-MS) method was described for the determination of glutaraldehyde in water. Glutaraldehyde in water reacted with 2,2,2-trifluoroethylhydrazine (TFEH) in a headspace vial and the formed TFEH derivatives were vaporized and adsorbed onto a fiber. The optimal HS-SPME conditions were achieved with a 50/30 μm-divinylbenzene-carboxen-polydimethylsiloxane fiber, 0.06% 2,2,2-TFEH, 25% salt, an extraction/derivatization temperature of 80 °C, a heating time of 30 min, and a pH of 6.5. The desorption was performed for 1 min at 240 °C. Under the established conditions, the lowest limits of detection were 0.3 μg/L and 0.1 μg/L in 6.0 mL of surface water and drinking water, respectively, and the intra- and inter-day relative standard deviation was less than 9.1% at concentrations of 50, 100 and 500 μg/L. The calibration curve showed good linearity with R = 0.9995 and R = 0.9993 in surface water and drinking water, respectively. This method is simple, amenable to automation and environmentally friendly.