Highly sensitive and selective high-performance liquid chromatography method for bioequivalence study of cefpodoxime proxetil in rabbit plasma via fluorescence labeling of its active metabolite

- Highly sensitive and selective method for the determination of CFA in rabbit plasma.
- This is the first HPLC-FL method concerning the quantitation of CFA in plasma.
- The developed method was 50 times more sensitive than reported HPLC methods.
- Plasma sample clean-up involves a simple protein precipitation procedure with no reconstitution step.
- The developed HPLC-FL method was applied successfully for bioequivalence study.