کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622185 | 1494523 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structure characterization of two novel polysaccharides from Colocasia esculenta (taro) and a comparative study of their immunomodulatory activities
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Two fractions of non-starch polysaccharides termed TPS-1 and TPS-2 were sequentially purified from the corms of Colocasia esculenta. Structural characterizations of TPS-1 and TPS-2 were determined. The average molecular weight of TPS-1 and TPS-2 were estimated to be 10.502 and 10.191â¯kDa, respectively. TPS-1 consisted of Rha (8.5%), Xyl (0.73%), Glc (88.57%), and Gal (2.56%), while TPS-2 consisted of Rha (3.54%), Arf (1.6%), Glc (87.92%), and Gal (6.94%). The presence of glycosidic linkages in the two fractions of polysaccharides were identified and were significantly different. TPS-2 exhibited a higher immunomodulatory activity than TPS-1 through an immunostimulation assay promoting NO, TNF-α, and IL-6 production in RAW 264.7 cells. Furthermore, TPS-2 could significantly enhance the phagocytosis ability of macrophages. The membrane receptors of TPS-2 were identified to be TLR2, TLR4, GR, and SR. Taken together, TPS-1 and TPS-2 could be considered as novel potential immunostimulants of food and pharmaceutical supplements for hypoimmunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 47-57
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 47-57
نویسندگان
Huixian Li, Zhou Dong, Xiaojia Liu, Huamin Chen, Furao Lai, Mengmeng Zhang,