کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622297 | 1494523 | 2018 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Liver-specific metabolomics characterizes the hepatoprotective effect of saponin-enriched Celosiae Semen extract on mice with nonalcoholic fatty liver disease
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کلمات کلیدی
SaponinSuccinic acid (PubChem CID: 1110)l-Isoleucine (PubChem CID: 6306)l-Proline (PubChem CID: 145742)Glutamic acid (PubChem CID: 611)GC–MS - GC-MSLinoleic acid (PubChem CID: 5280450) - اسید لینولئیک (PubChem CID: 5280450)Palmitic acid (Pubchem CID: 985) - اسید پالمیتیک (Pubchem CID: 985)Nonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Celosiae Semen, derived from the seeds of Celosia argentea L., has a long history of therapeutic uses for liver diseases in China and Japan. Phytochemical researches revealed a series of saponins from Celosiae Semen, which showed a variety of important pharmacological properties such as anti-hyperlipidemia and hepatoprotection. However, the exact protection mechanism is still looking forward to further elucidation. In present study, a liver-specific metabolomics approach based on gas chromatography-mass spectrometry (GC-MS) was applied to investigate the hepatoprotective effect of saponin-enriched Celosiae Semen extract (SECSE) under high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD). Orthogonal partial least squares discriminant analysis (OPLS-DA) was used to identify different metabolic profiles of liver from C57BL/6 mice. At the meantime, serum biochemical analysis and liver histopathological examination were performed. The results suggested that SECSE has effective protection to NAFLD, which is associated with energy metabolism, amino acid metabolism and lipid metabolism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 185-194
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 185-194
نویسندگان
Feng-Jie Liu, Dan Liang, Lan-Yun Miao, Ping Li, Hui-Jun Li,