کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622317 | 1494523 | 2018 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytoprotective effect and purification of novel antioxidant peptides from hazelnut (C. heterophylla Fisch) protein hydrolysates
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, antioxidant fraction (C2) has been obtained from a hazelnut processing by-product. The C2 exhibited strong antioxidant and cytoprotective effect against Ang II induced oxidant injury via up-regulation of SOD and heme oxygenase-1 (HO-1) levels and down-regulation of xanthine oxidase-1 (XO-1) level to inhibit the production of ROS synthesis in human umbilical vein endothelial cells (HUVECs). LC-ESI-MS/MS results revealed that C2 was found to include six novel peptides and their amino acid sequences were ADGF (408.16â¯Da), AGGF (350.16â¯Da), AWDPE (616.25â¯Da), DWDPK (659.29â¯Da), ETTL (462.23â¯Da), and SGAF (380.17â¯Da). All six synthetic peptides showed excellent antioxidant activity. Especially, the ADGF peptide exhibited the highest ABTS radical scavenging activity and DPPH radical scavenging ability among them. Therefore, the peptides isolated from wild hazelnut protein hydrolysates may be used as potential antioxidants in the food and drug industries.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 203-215
Journal: Journal of Functional Foods - Volume 42, March 2018, Pages 203-215
نویسندگان
Chunlei Liu, Dayong Ren, Jingjing Li, Li Fang, Ji Wang, Jingsheng Liu, Weihong Min,