کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7622499 1494525 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-diabetic effects of chondroitin sulfate on normal and type 2 diabetic mice
ترجمه فارسی عنوان
اثرات ضد دیابتی کاندرویتین سولفات بر روی موش های دیابتی معمولی و نوع 2
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
We evaluated the inhibitory effects of CS with different molecular weights from 170,000 to 10,000 Da on a-glucosidase activity in vitro. Low-molecular-weight CS (<16,000 Da) showed a higher inhibition of a-glucosidase activity than high-molecular-weight CS. In addition, we examined the effects of a single administration of low-molecular-weight CS on postprandial blood glucose in ICR mice. Low-molecular-weight CS inhibited the elevation of postprandial blood glucose in mice loaded with sucrose or starch as the source of carbohydrates. Finally, we investigated the anti-diabetic effects of daily administration of low- molecular-weight CS using type 2 diabetes model KK-Ay mice. The elevation of fasting blood glucose was inhibited in the CS group. These results suggest that the administration of low-molecular-weight CS prevents the elevation in the postprandial blood glucose level by reducing the digestion of carbohydrates in the gastrointestinal tract, leading to reductions of hyperglycemia in KK-Ay mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 40, January 2018, Pages 336-340
نویسندگان
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