کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7622556 | 1494527 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chickpea-supplemented diet alters the gut microbiome and enhances gut barrier integrity in C57Bl/6 male mice
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کلمات کلیدی
KLF4FITCFDRRDPJunctional adhesion molecule AJAM-APICRUSt5-ethynyl-2′-deoxyuridine - 5-ethynyl-2'-deoxyuridineEdU - EDUH&E - H & EOTU - OTPhylogenetic Investigation of Communities by Reconstruction of Unobserved States - بررسی فیلوژنتیک جوامع با بازسازی دولتهای غیرمتعهدKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوbasal diet - رژیم غذایی پایهKrüppel-like factor 4 - عامل کریپال مانند 4fluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتSTAMP - مهرfalse discovery rate - میزان کشف کاذبribosomal database project - پروژه پایگاه داده ریبوزوم
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Chickpea-supplemented diet alters the gut microbiome and enhances gut barrier integrity in C57Bl/6 male mice Chickpea-supplemented diet alters the gut microbiome and enhances gut barrier integrity in C57Bl/6 male mice](/preview/png/7622556.png)
چکیده انگلیسی
Pulses are rich in fermentable fibre and phenolic compounds that have the potential to modify baseline function within the gut microenvironment (microbiota and epithelial barrier), thereby mitigating gut-associated diseases. The objective was to assess the gut health promoting effects of dietary chickpea in C57BL/6 mice consuming a 20% cooked chickpea flour diet (CK) or an isocaloric control diet for 3Â weeks. Gut health was enhanced by CK including (i) colon crypt mucus content and mucin mRNA expression, (ii) crypt length, proliferation, and epithelial barrier junctional components expression, (iii) anti-microbial defenses, and (iv) altered cecal and fecal microbiota community structure (e.g. increased Prevotella) with enhanced metagenomic functions (e.g. increased flavonoid biosynthesis, butanoate metabolism), and microbial activity (increased short chain fatty acid production). Collectively, CK modulated the baseline function of the colonic microenvironment (microbiome and epithelial barrier), thereby priming colonic function such that the severity of gut-associated diseases could be mitigated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 38, Part B, November 2017, Pages 663-674
Journal: Journal of Functional Foods - Volume 38, Part B, November 2017, Pages 663-674
نویسندگان
Jennifer M. Monk, Dion Lepp, Wenqing Wu, Daniela Graf, Laurel H. McGillis, Adeel Hussain, Christine Carey, Lindsay E. Robinson, Ronghua Liu, Rong Tsao, Yolanda Brummer, Susan M. Tosh, Krista A. Power,