کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7623238 1494541 2016 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Partial characterization and anticancer activities of purified glycoprotein extracted from green seaweed Codium decorticatum
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Partial characterization and anticancer activities of purified glycoprotein extracted from green seaweed Codium decorticatum
چکیده انگلیسی
Glycoprotein (GLP) with a molecular mass of ~48 kDa was isolated from Codium decorticatum. Further, characterization of GLP and its potent anti-cancer activities was discussed. GLP is a glycoprotein with 36.24% carbohydrate, composed of rhamnose, galactose, glucose and mannose with a mole ratio of 38:30:26:6. Rhamnose and galactose are thus the main monosaccharides in GLP. FT-IR and NMR spectra proved that GLP contained protein and carbohydrate portions with (1→4)-linked β-galactose residues and β-linked glucose residues. Secondary structure of GLP was estimated using circular dichroism (CD) analysis. Furthermore mass spectrometric analysis was performed for identification of protein using mascot search. The findings of this study serve as a reference for better understanding of the bioactivity of glycoprotein in green algae. Analysis of anticancer potential of this GLP revealed a remarkable inhibition of cell growth in breast, cervical and lung cancer cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 25, August 2016, Pages 323-332
نویسندگان
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