کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7623319 1494540 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Olive oil, compared to a saturated dietary fat, has a protective role on atherosclerosis in niacin-treated mice with metabolic syndrome
ترجمه فارسی عنوان
روغن زیتون در مقایسه با یک چربی اشباع شده دارای نقش محافظتی در آترواسکلروز در موشهای تحت درمان با نیاسین با سندرم متابولیک
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
We aimed to investigate the impact of high-fat low-cholesterol diets rich in saturated fatty acids (HFLCD-SFAs), monounsaturated FAs (HFLCD-MUFAs) or MUFAs + omega-3 long-chain polyunsaturated FAs (HFLCD-PUFAs) in combination with niacin (NA) on atherosclerotic plaque characteristics in a mouse model (Lepob/obLDLR−/−) of metabolic syndrome (MetS). Compared to a low-fat low-cholesterol diet (LFLCD), HFLCDs increased body weight, triglycerides, insulin, pro-inflammatory cytokines, and circulating monocytes, contributing the HFLCD-SFAs to a predominance of a classical pro-inflammatory Ly6Chi population, whereas HFLCD-MUFAs and HFLCD-PUFAs to a non-classical patrolling Ly6Clo population. HFLCDs promoted atherosclerosis in the aortic roots of animals but the plaque size, collagen, and macrophage content were higher with the HFLCD-SFAs than with the HFLCD-MUFAs or HFLCD-PUFAs. Furthermore, HFLCD-SFAs promoted the intra-plaque accumulation of M1 macrophages, whereas HFLCD-MUFAs and HFLCD-PUFAs favoured the accumulation of M2 macrophages. These data suggest that dietary MUFAs had advantage over SFAs to prevent atherosclerotic events in the NA-treated MetS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 26, October 2016, Pages 557-564
نویسندگان
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