کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7623476 1494546 2016 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue
چکیده انگلیسی
Cocoa flavan-3-ols have been shown to exert a positive influence on obesity-related metabolic risk factors. This study evaluated the effects of cocoa powder (Co), cocoa extract (Co-Ex) and its main flavanols (Epi, Cat and PB2) on the expression of genes involved in WAT lipid metabolism in a rat model of hypercaloric diet-induced obesity. Co, Co-Ex and Epi are associated with adipogenesis, β-oxidation and energy expenditure in WAT linked to upregulating the expression of peroxisome-proliferator-activated receptor γ (PPARγ), PPARα, PPARγ coactivator 1α (PGC1α), sirtuin 1 (SIRT1) and uncoupling protein 1 (UCP1). Additionally, these treatments are associated with decreases in body weight gain and total fat mass and insulin resistance, reduced lipogenesis, and inflammation related to downregulating acetyl-CoA carboxylase gene expression, decreasing TNF-α and increasing ApN concentrations in WAT. Co, Co-Ex and Epi may be considered to be potential agents for the treatment of obesity-related metabolic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 54-67
نویسندگان
, , , , ,