کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623476 | 1494546 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cocoa powder, cocoa extract and epicatechin attenuate hypercaloric diet-induced obesity through enhanced β-oxidation and energy expenditure in white adipose tissue
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Cocoa flavan-3-ols have been shown to exert a positive influence on obesity-related metabolic risk factors. This study evaluated the effects of cocoa powder (Co), cocoa extract (Co-Ex) and its main flavanols (Epi, Cat and PB2) on the expression of genes involved in WAT lipid metabolism in a rat model of hypercaloric diet-induced obesity. Co, Co-Ex and Epi are associated with adipogenesis, β-oxidation and energy expenditure in WAT linked to upregulating the expression of peroxisome-proliferator-activated receptor γ (PPARγ), PPARα, PPARγ coactivator 1α (PGC1α), sirtuin 1 (SIRT1) and uncoupling protein 1 (UCP1). Additionally, these treatments are associated with decreases in body weight gain and total fat mass and insulin resistance, reduced lipogenesis, and inflammation related to downregulating acetyl-CoA carboxylase gene expression, decreasing TNF-α and increasing ApN concentrations in WAT. Co, Co-Ex and Epi may be considered to be potential agents for the treatment of obesity-related metabolic disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 54-67
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 54-67
نویسندگان
Griselda Rabadan-Chávez, Lucia Quevedo-Corona, Angel Miliar Garcia, Elba Reyes-Maldonado, MarÃa Eugenia Jaramillo-Flores,