کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623553 | 1494546 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Using molecular docking screening for identifying hyperoside as an inhibitor of fatty acid binding protein 4 from a natural product database
ترجمه فارسی عنوان
استفاده از غربالگری مولکولی برای شناسایی هیپرزاید به عنوان بازدارنده پروتئین 4 اتصال دهنده اسید چرب از یک پایگاه داده محصول طبیعی
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The inhibition of fatty acid binding protein 4 (FABP4) by using small molecules could potentially provide therapeutic opportunities for metabolic disorders treatment. According to the results of our in-house virtual screening on the herbal molecules database, this study reports flavonols as an ideal scaffold for FABP4 inhibitors development. Among the popular flavonols examined, we identified hyperoside as a promising FABP4 inhibitor. Identical to the well-known FABP4 inhibitor BMS309403, hyperoside induced lipid accumulation and upregulated peroxisome proliferator-activated receptor γ (PPARγ) protein expression during the adipocyte differentiation process. Furthermore, both PPARγ antagonist and FABP4 overexpression attenuated hyperoside-induced adipogenesis, indicating that hyperoside promoted adipogenesis in adipocytes via the FABP4/PPARγ pathway. We anticipate hyperoside to be a promising, novel FABP4 inhibitor for antidiabetic drug development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 159-170
Journal: Journal of Functional Foods - Volume 20, January 2016, Pages 159-170
نویسندگان
Yan Wang, Huang-Quan Lin, Chu-Ying Xiao, Wai-Kit Law, Jian-Shu Hu, Tsz-Ming Ip, David Chi-Cheong Wan,