کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623593 | 1494544 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antidiabetic effect of new chromane isolated from Dillenia indica L. leaves in streptozotocin induced diabetic rats
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
The chemical constituents of Dillenia indica were isolated together with evaluation of their antioxidant and antidiabetic activity. Alcoholic extract of D.âindica (DAE) was subjected to column chromatography for the isolation of compounds and it yielded a new chromane 3,5,7,-trihydroxy-2-(4-hydroxybenzyl)-chroman-4-one. The structure was determined by 1H, 13C-NMR and ESIMS. DAE (100, 200 and 400âmg/kg) and chromane (5 and 10âmg/kg) were administered to streptozotocin (STZ) (50âmg/kg) induced diabetic rats to assess their effect on fasting blood glucose, serum insulin and lipid levels. Oral administration of chromane and DAE significantly attenuated the elevated fasting blood glucose, lipid levels and oxidative stress. The results indicated that DAE and chromane isolated from D.âindica possessed antioxidant and antidiabetic activity and could be a therapeutic agent for regulating several pharmacological targets for management of diabetes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 547-555
Journal: Journal of Functional Foods - Volume 22, April 2016, Pages 547-555
نویسندگان
Navpreet Kaur, Lalit Kishore, Randhir Singh,