کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7623925 | 1494547 | 2015 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
1H NMR-based metabonomics of the protective effect of Curcuma longa and curcumin on cinnabar-induced hepatotoxicity and nephrotoxicity in rats
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Curcuma longa is a perennial herb that is widely cultivated extensively in Asia and Africa. Curcumin is a major constituent of C.âlonga. A metabonomics approach based on high-resolution 1H nuclear magnetic resonance spectroscopy was applied to investigate the toxicity protective effects of C.âlonga and curcumin in rats under cinnabar induced hepatotoxicity and nephrotoxicity. Partial least squares-discriminant analysis (PLS-DA) was performed to identify different metabolic profiles of urine and serum from rats. Liver and kidney histopathology examinations and serum clinical chemistry analysis were also performed. The significant difference in metabolic profiling of urine and serum of the rats was observed among cinnabar treated group, control group, co administration of C.âlonga and cinnabar, co administration of curcumin and cinnabar group. The results suggested that C.âlonga and curcumin have the effective protection function through regulating the energy metabolism, intestinal microflora and amino acid metabolism to the liver and kidney injury induced by cinnabar.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 459-467
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 459-467
نویسندگان
Haifeng Wang, Guangyue Su, Gang Chen, Jiao Bai, Yuehu Pei,