کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7623925 1494547 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
1H NMR-based metabonomics of the protective effect of Curcuma longa and curcumin on cinnabar-induced hepatotoxicity and nephrotoxicity in rats
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
1H NMR-based metabonomics of the protective effect of Curcuma longa and curcumin on cinnabar-induced hepatotoxicity and nephrotoxicity in rats
چکیده انگلیسی
Curcuma longa is a perennial herb that is widely cultivated extensively in Asia and Africa. Curcumin is a major constituent of C. longa. A metabonomics approach based on high-resolution 1H nuclear magnetic resonance spectroscopy was applied to investigate the toxicity protective effects of C. longa and curcumin in rats under cinnabar induced hepatotoxicity and nephrotoxicity. Partial least squares-discriminant analysis (PLS-DA) was performed to identify different metabolic profiles of urine and serum from rats. Liver and kidney histopathology examinations and serum clinical chemistry analysis were also performed. The significant difference in metabolic profiling of urine and serum of the rats was observed among cinnabar treated group, control group, co administration of C. longa and cinnabar, co administration of curcumin and cinnabar group. The results suggested that C. longa and curcumin have the effective protection function through regulating the energy metabolism, intestinal microflora and amino acid metabolism to the liver and kidney injury induced by cinnabar.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 459-467
نویسندگان
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