کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7624256 | 1494547 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of dietary supplementation of ginger and turmeric rhizomes on angiotensin-1 converting enzyme (ACE) and arginase activities in L-NAME induced hypertensive rats
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Ginger and turmeric rhizomes are used in folk medicine for the treatment of hypertension but the mechanism remains unclear. This study evaluated the effects of ginger and turmeric rhizomes on angiotensin 1 converting enzyme (ACE) and arginase activities in hypertensive rats. The animals were divided into seven groups (nâ=â10): normotensive control rats; hypertensive rats; hypertensive rats treated with atenolol; normotensive diet group supplemented with turmeric rhizomes; hypertensive rats supplemented with turmeric rhizomes; normotensive diet group supplemented with ginger rhizomes; and hypertensive diet group supplemented with ginger rhizomes respectively. After 14 days of pre-treatment with ginger and turmeric rhizomes-supplemented diet, the animals were induced with hypertension by oral administration of NÏ-nitro-L-arginine methyl ester hydrochloride (L-NAME). The results revealed a significant increase in ACE and arginase activities in hypertensive rats when compared with the control. However, pre-treatment with both rhizomes respectively caused a significant decrease in ACE and arginase activities with a concomitant increase in nitric oxide (NO) level. These activities could further buttress their antihypertensive benefits in folk medicine.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 792-801
Journal: Journal of Functional Foods - Volume 17, August 2015, Pages 792-801
نویسندگان
Ayodele Jacob Akinyemi, Gustavo Roberto Thome, Vera Maria Morsch, Naiara Stefanello, Jeferson Ferraz Goularte, Adriane Belló-Klein, Ganiyu Oboh, Maria Rosa Chitolina Schetinger,