کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624512 1494553 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson's disease
ترجمه فارسی عنوان
فعالیت های ایمونومولدولسیون پلی ساکارید از کلرلا پنیوئیدوز در یک مدل موش از بیماری پارکینسون
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
Neuro-inflammation is implicated as a major pathogenic factor in Parkinson's disease (PD). Dietary supplements of Chlorella pyrenoidosa possess great anti-inflammatory activities, but its neuroprotective effect remains unclear. The aim of this study was to investigate the effects of polysaccharides from Chlorella pyrenoidosa (CPS) on motor activity, dopamine expressions, microglial activation, and peripheral immunomodulatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. The results of this study indicated that CPS reduced bradykinesia, inhibited the loss of striatal dopamine and its metabolites, and led to an increase in tyrosine hydroxylase in PD mice. In addition, CPS also suppressed the striatal Emr1 expression and tumor necrosis factor-α, interleukin-1β and IL-6 levels in serum. Furthermore, the gut immune biomarkers such as serum diamine oxidase and small intestinal secretory immunoglobulin A were enhanced by CPS treatment. These findings demonstrate that CPS has protective effect in MPTP-induced neurotoxicity in this model of PD via its immunomodulatory action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 11, November 2014, Pages 103-113
نویسندگان
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