کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624602 1494550 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transgenic flax overexpressing polyphenols as a potential anti-inflammatory dietary agent
ترجمه فارسی عنوان
پلی فنول بیش از حد کتان ترانس ژن به عنوان یک عامل رژیم غذایی ضد التهابی بالقوه
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
چکیده انگلیسی
The influence of chronic administration of seed cake of genetically modified flax W92/72, which overexpressed polyphenols, on diet-evoked inflammation in the liver and other physiological disturbances was examined. High-fat-diet-induced rat obesity models were administered ad libitum the experimental diets (standard, high-fat with lard, and standard and high-fat diets enriched with 30% seed cake of non-transgenic or transgenic flax) for 14 weeks. The beneficial effects of transgenic seed cake were related to carbohydrate metabolism, serum total antioxidant capacity and lipid peroxidation. The levels of the liver pro-inflammatory cytokines tumor necrosis factor-α and interleukin-6 were decreased in the transgenic and non-transgenic seed cake groups. Transgenic seed cake consumption elevated the anti-inflammatory cytokines interleukin-4 and -10. The flaxseed cake groups had improved liver ultra-structure. Diet supplementation with genetically modified flax W92/72 seed cake may contribute to solving health problems resulting from high-energy diet consumption.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 14, April 2015, Pages 299-307
نویسندگان
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