کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
7624793 1494556 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08)
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08)
چکیده انگلیسی
We previously demonstrated that Brazilian propolis AF-08 exhibits anti-influenza virus activity in vitro and in vivo. To characterize its effective components, flavonoids and related compounds involved in AF-08 were examined for their anti-influenza virus activity in vitro and in vivo. Four flavonoids and three phenyl propanoids were selected as possible components of AF-08 by HPLC. Among them, apigenin, kaempferol, and coumaric acid exhibited significant antiviral activity against oseltamivir- and peramivir-sensitive and oseltamivir- and peramivir-resistant influenza viruses in plaque reduction assays and kaempferol did not interfere with virus adsorption and/or invasion in vitro. The oral administration of kaempferol was significantly effective in prolonging survival times and reducing virus titers in bronchoalveolar lavage fluids prepared from influenza virus-infected mice. Thus, kaempferol, a component of AF-08, exhibited therapeutic efficacy in limiting influenza symptoms in mice and is indicated to contribute to the in vivo anti-influenza virus activity of propolis AF-08 as a crude extract.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 8, May 2014, Pages 214-223
نویسندگان
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