کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7628891 | 1494607 | 2016 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
A screen for known PDE-5 inhibitors in a dietary supplement product marketed for “enhanced sexual performance” detected a compound that structurally resembled chloropretadalafil, a known analog of tadalafil. The compound was isolated from the supplement matrix using high performance liquid chromatography with ultraviolet detection (HPLC-UV) and a fraction collector, and was further characterized using gas chromatography with Fourier Transform infrared detection and mass spectral detection (GC/FT-IR/MS), as well as high resolution mass spectrometry (HRMS). The analog had an accurate mass of m/z 441.1216 (error is 0.8706Â ppm) for the protonated species [M+H]+, corresponding to a molecular formula of C23H22ClN2O5. HRAM and GC/FT-IR/MS mass spectral fragmentation data suggested that the modification is a chloropropanoyl moiety extending from the nitrogen on the piperidine ring of chloropretadalafil. The proposed new analog has been named chloropropanoylpretadalafil.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 128, 5 September 2016, Pages 360-366
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 128, 5 September 2016, Pages 360-366
نویسندگان
Sara E. Kern, Lisa M. Lorenz, Adam Lanzarotta, Elisa A. Nickum, Jonathan J. Litzau,