Pharmacokinetics in rats and tissue distribution in mouse of berberrubine by UPLC-MS/MS

- The pharmacokinetics and tissue distribution study of berberrubine were reported.
- First report of UPLC-MS/MS method for the determination of berberrubine in rat plasma.
- First report of the bioavailability of berberrubine in rat.
- The level of berberrubine in liver is highest, then followed by kidney, spleen and heart.
- A BP-ANN tissue distribution model of berberrubine in mouse was developed.