Application of an ultra-performance liquid chromatography method with tandem mass spectrometry to pharmacokinetics, tissue distribution and excretion in the study of DAT-230, a novel tubulin-binding agent candidate, in rats

- This is the first report for the thorough studies of the pharmacokinetics and tissue distribution profiles of DAT-230 in rats.
- The plasma sample preparation procedure was one-step precipitation of proteins.
- The mean pharmacokinetic parameters of t1/2 and AUC0-12 were 1.1 ± 0.4 h and 861.0 ± 281.2 ng h/mL, respectively.