Simultaneous quantification of three active alkaloids from a traditional Chinese medicine Ramulus Mori (Sangzhi) in rat plasma using liquid chromatography-tandem mass spectrometry

- Simultaneous determination of DNJ, fagomine and DAB in rat plasma was done.
- A simple, selective and sensitive LC-MS/MS method was developed and validated.
- The method was applied to a pharmacokinetic study of mulberry twig in rats.