کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7629821 | 1645359 | 2015 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine Sensitive and accurate liquid chromatography-tandem mass spectrometry methods for quantitative determination of a novel hepatitis C NS5B inhibitor BMS-791325 and its active metabolite in human plasma and urine](/preview/png/7629821.png)
چکیده انگلیسی
- Quantitation of BMS-791325 and active metabolite in plasma and urine by LC-MS/MS.
- The validation results demonstrate the method is accurate, precise, and reproducible.
- Coadministered famotidine and ritonavir did not affect the LC-MS/MS method.
- Crossvalidation after method transfers demonstrated method equivalency.
- The plasma method was used for pharmacokinetic evaluation in many clinical studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 107, 25 March 2015, Pages 17-23
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 107, 25 March 2015, Pages 17-23
نویسندگان
Hao Jiang, Roger Demers, Hamza Kandoussi, Richard Burrell, Timothy Eley, Pathanjali Kadiyala, Laura Cojocaru, Chanda Baker, John Ryan, Anne-Françoise Aubry, Mark E. Arnold, Jianing Zeng,