Application of vibrational spectroscopy, thermal analyses and X-ray diffraction in the rapid evaluation of the stability in solid-state of ranitidine, famotidine and cimetidine

- Stability testing of ranitidine, famotidine and cimetidine in a solid state is presented.
- Demonstration of application of NIR, FTIR, Raman, XRD, DSC to estimate stability.
- Explanation of decomposition of powders is demonstrated.
- Variations and/or Simca model of FTIR and NIR spectra is analyzed.
- XRD and DSC methods provide a fast screening for estimation of solid state stability.