Solid-state characterization of sertraline base-β-cyclodextrin inclusion complex

- We converted sertraline hydrochloride salt into the free base.
- Sertraline base and β-CD form a 1:1 inclusion complex in the solid-state.
- Sertraline base-β-CD complex shows high apparent stability constant.
- Sertraline base-β-CD complex shows the conformational changes from the constituent.