Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate

- A simple validated bioanalytical LC-MS/MS assay for GSK2126458 has been reported.
- The assay has successfully been validated in the 4-4000 ng/ml range for mouse plasma.
- The assay could also be used for tumor homogenate samples.
- Tumor and plasma drug levels in mice with neuroblastoma xenografts have been reported.