N-Acetyl-S-(N,N-diethylcarbamoyl) cysteine in rat nucleus accumbens, medial prefrontal cortex, and in rat and human plasma after disulfiram administration

- Validation of a selective and sensitive HPLC-MS/MS assay for DETC-NAC is described.
- DETC-NAC is confirmed as a metabolite of disulfiram.
- Microdialysis studies demonstrate that DETC-NAC can cross the blood-brain barrier.
- Results discussed in the context of disulfiram use as a putative addiction treatment.