A rapid and sensitive UPLC-MS/MS method for determination of HZ08 in rat plasma and tissues: Application to a pharmacokinetic study of liposome injections

- A UPLC-MS/MS method was developed to determine HZ08 in rat plasma and tissues.
- The total analysis time was 4.0 min.
- The method was applied to pharmacokinetic study of HZ08 in rats.
- HZ08 had linear pharmacokinetic properties with a rapid elimination phase.
- The major distribution tissues of HZ08 in rats were lung, spleen and liver.