Identification of process related trace level impurities in the actinide decorporation agent 3,4,3-LI(1,2-HOPO): Nozzle-skimmer fragmentation via ESI LC-QTOFMS

- A LC-ESI TOFMS method was developed and used for the impurity control of 3,4,3-LI(1,2-HOPO).
- The most recent commercial batch used in most pre-clinical studies was examined.
- A complete overview of all relevant impurities is provided.